Aapki Antara is the story of five-year-old cute and adorable girl Antara. She is born to Anuradha who had a relationship out of wedlock with Aditya. When Anuradha dies in a car accident, Antara is orphaned. It is now the responsibility of Aditya to take her home to his wife Vidya and son Abhishek and accept her as a part of the family. With Antara in their life, things are not the same again in Aditya and Vidya's lives. Antara does not behave like a normal child. She cannot express emotions and lives in her own world! To the outside world she is a day dreamer and a slow child. During the course of time, Aditya discovers that Antara suffers from a condition called autism. He is then faced with a challenge to bring up his special child and get her accepted by the society. Through the story, the show guides people to understand the needs of people suffering from this condition and to deal with them sensitively.